Ability of Bacillus subtilis for treatment of rhinosinusitis in a murine model
- Author:
Nguyen Thi Ngoc Tuyet
- Publication Type:Journal Article
- Keywords:
Rhinosinusitis
- MeSH:
Sinusitis;
Bacillus subtilis;
Therapeutics
- From:Journal Ho Chi Minh Medical
2005;9(4):215-219
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Probiotic preparations of Bacillus subtilis (B. subtilis) have been used by humans to treat and prevent the common forms of diarrhea caused by bacteria and virus, as well as other infections. To develop preparations of B. subtilis as an intranasal form, the authors studied the persistence and the antirhinopharyngitis of B. subtilis given nasally to mice. Substantial numbers of B. subtilis were still present in the nasopharynx 6 days after inoculation. The reduction in bacterial growth was similar to the positive controls. Also a reduced histopathological score was evident in corresponding with treating by ampicillin and prednisolone. Specifically, the authors obtained superior results in mice having administration of a dose of B. subtilis a day before inoculation of S. pneumoniae
