ISAba15 Inserted into Outer Membrane Protein Gene carO in Acinetobacter baumannii.

Author: Dae Hun KIM ¹ ; Kwan Soo KO
Author Information

1. Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea. ksko@skku.edu
Publication Type:Brief Communication
Keywords: Carbapenem; Insertion sequence (IS); Antimicrobial resistance
MeSH: Acinetobacter baumannii*; Colistin; Drug Resistance, Bacterial; Membrane Proteins*
From:Journal of Bacteriology and Virology 2015;45(1):51-53
CountryRepublic of Korea
Language:English
Abstract: We identified ISAba15 inserted into the carO gene in an Acinetobacter baumannii isolate. The insert disrupted the lpxD gene, resulting in colistin resistance in A. baumannii. Persistence in carbapenem resistance in A. baumannii isolates with an intact carO gene indicates that loss of the encoded CarO may play a minor role in carbapenem resistance.