Heat Shock Protein 90 (HSP90) and Immune Regulation.

Author: Bo Kyung KIM ¹ ; So Youn WOO
Author Information

1. Departments of Microbiology, School of Medicine, Ewha Womans University, Seoul, Korea. soyounwoo@ewha.ac.kr
Publication Type:Review
Keywords: Heat shock protein 90 (HSP90); Anti-inflammatory; HSP90 inhibitor; IL-17; Act1
MeSH: Autoimmune Diseases; Heat-Shock Proteins*; Immunity, Cellular; Interleukin-17; Transcription Factors
From:Journal of Bacteriology and Virology 2015;45(1):62-66
CountryRepublic of Korea
Language:Korean
Abstract: Heat shock protein 90 (HSP90) is involved in conformational and structural maturation of signalling molecules and transcription factors in immune reaction. HSP90 inhibitors induce immune modulation via anti-inflammatory effect, regulating humoral and cellular immune responses. Therefore, HSP90 inhibitors potentially useful target for the autoimmune disease and chronic inflammatory diseases.