Effects of Mg2+ Intravenous Pretreatment on Brain Energy Metabolism in Acute Ischemic-Reperfusion Model in Cats: 31P and 1H Magnetic Resonance Spectroscopic Study.
- Author:
Eun Ha SUK
1
;
Ji Young KANG
;
Sung Kwan CHUN
;
Pyung Hwan PARK
;
Kun Ho LIM
;
Jung Hee LEE
;
Tae Hwan LIM
Author Information
1. Department of Anesthesiology, Asan Medical Center,College of Medicine, University of Ulsan, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Brain;
ischemia;
metabolism;
Pharmacology;
Mg2+
- MeSH:
Animals;
Aspartic Acid;
Blood Pressure;
Brachiocephalic Trunk;
Brain Ischemia;
Brain*;
Cats*;
Energy Metabolism*;
Hydrogen-Ion Concentration;
Ischemia;
Ligation;
Metabolism;
Models, Animal;
Pharmacology;
Reperfusion;
Vena Cava, Inferior
- From:The Korean Journal of Critical Care Medicine
1999;14(2):132-136
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGOUND: This study was purposed to evaluate the effects of Mg2+ pretreatment on cerebral ischemic injury in cats. METHODS: Global cerebral ischemia was induced by ligation of both innominate arteries following ligation of inferior vena cava under lowered mean blood pressure for 20 minutes followed by 3 hrs of reperfusion. Ten cats were divided into 2 groups: Group 1 (n=5) is the control group, for group 2 (n=5) (Mg2+ group), the animals were pretreated with 90 mg/kg of Mg2+ intravenously before subjected to ischemia. RESULTS: Phosphocreatine/inorganic phosphate (Pcr/Pi) and pH decreased after ischemia and did not recovered during reperfusion. And there were no significant differences between the two groups. The ratios of lactate/N-acetyl aspartate (Lac/NAA) and lactate/creatine (Lac/Cr) increased after ischemia and not recovered during reperfusion. But the ratios were higher for the group 2 than the group 1 during reperfusion (p<0.05). For the Mg2+ group, blood pressure during reperfusion was lower than the control group. CONCLUSIONS: Mg2+ intravenous pretreatment had no protective effect on this global cerebral ischemia animal model. Even it deteriorated brain energy metabolism by lowering blood pressure.
