Effect of Pdx1 Expression after Sox9 Depletion in the Early Pancreatic Development in African Clawed Frog (Xenopus laevis).
- Author:
Byung Yong PARK
1
;
Li Guang LI
;
Eun Hye CHOI
;
Mong Yong JUNG
;
Ki Tak KWON
;
Yeon Ho JEONG
;
Jong Youn KIM
;
In Shik KIM
;
Byung Keon PARK
;
Young Hoon LEE
Author Information
1. Department of Oral Anatomy, Chonbuk National University,Jeonju, Korea. yhlee@chonbuk.ac.kr
- Publication Type:Original Article
- Keywords:
African clawed frog;
Pancreatic development;
Sox9;
Pdx1
- MeSH:
Animals;
Endocrine Glands;
Gene Expression;
Hoof and Claw*;
Pancreas;
Xenopus
- From:Korean Journal of Anatomy
2007;40(1):1-10
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The pancreas is a mixed exocrine and endocrine gland involved in the control of many homeostatic functions.During embryogenesis,the pancreas arises from dorsal and ventral evaginations of the foregut,which subse- quently fuse into a single organ.The characterization of early genes expressed in the developing pancreas is critical to understand its specification and differentiation.Pdx1 is one of the earliest markers of pancreatic development and a key molecule in its development.Sox proteins form a large class of transcriptional regulators implicated in the control of a variety of developmental processes.One member of this family,Sox9,is expressed in the developing pancreas, but little is known about the function of Sox9 in the developing pancreas.We further investigated Sox9 function during pancreatic development in Xenopus .Using a hormone-inducible inhibitory mutant of Sox9 ,we found that Pdx1 expres- sion was reduced in the ventral pancreatic buds in Sox9-depleted embryos.We suggest that Sox9 gene expression may be involved in pancreatic development in Xenopus.
