The Effect of Cefazolin on Mechanical Properties and Antibacterial Reactions of Calcium Phosphate Cement.
10.4055/jkoa.2011.46.4.273
- Author:
Ki Dae KWON
1
;
Jae Suk CHANG
;
Soo Ho LEE
;
Dong Ho LEE
;
Kang Sik LEE
;
Ji Hyo HWANG
;
Hee Sang LEE
;
Seong Eun BYUN
Author Information
1. Department of Orthopedic Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Korea. shlee2@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
calcium phosphate cement;
cefazolin;
compressive strength;
antibacterial
- MeSH:
Alginates;
Calcium;
Calcium Phosphates;
Cefazolin;
Compressive Strength;
Dinucleoside Phosphates;
Durapatite;
Exercise Test;
Fungi;
Glucuronic Acid;
Hexuronic Acids;
Porosity;
Sodium
- From:The Journal of the Korean Orthopaedic Association
2011;46(4):273-281
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study is to evaluate the change of mechanical properties and the effect of antibacterial reactions in calcium phosphate cement (CPC) mixed with cefazolin. MATERIALS AND METHODS: We made CPC and a sodium alginate solution and we mixed in variable dosages of cefazolin and then we made a standard sized cement mold. With that we performed compression stress tests, drug releasing tests and antibacterial tests. RESULTS: We found the typical appearance of hydroxyapatite (HA) in the cement mixed with cefazolin. The compressive strength of the cement mixed with cefazolin was higher than that of the cement not mixed with cefazolin and the higher strength cement had a smaller pore size and less porosity. The sodium alginate solution showed the maximum compressive strength at 2 & 4 wt%, but this was decreased at 6 wt%. Cefazolin was released in proportion to the concentration for the first 8 days on the drug releasing test and then a similar amount was released until the tenth day. An antibacterial effect was detected at all dosages of cefazolin on the antibacterial test. CONCLUSION: The compressive strength of the cement mixed with cefazolin was higher than that of the cement not mixed with cefazolin. The drug was released from the cement in a proper fashion and the antibacterial effect was preserved.
