Initiation of Continuous Renal Replacement Therapy and Clinical Outcome in Septic Shock Patients with Acute Kidney Injury.
10.4266/kjccm.2012.27.1.29
- Author:
Seung Mok RYOO
1
;
Won Young KIM
;
Sang Sik CHOI
;
Jin Won HUH
;
Sang Bum HONG
;
Chae Man LIM
;
Younsuck KOH
Author Information
1. Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
mortality;
renal replacement therapy;
sepsis
- MeSH:
Acute Kidney Injury;
Blood Urea Nitrogen;
Critical Illness;
Humans;
Intensive Care Units;
Male;
Renal Replacement Therapy;
Sepsis;
Shock, Septic
- From:The Korean Journal of Critical Care Medicine
2012;27(1):29-35
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Initiation of renal replacement therapy (RRT) in critically ill septic shock patients with acute kidney injury is highly subjective and may influence outcome. The aim of this study is to evaluate the relationship between initiation of RRT and 28 day mortality in patients with severe sepsis and septic shock (SSSS). METHODS: All patients diagnosed with SSSS and treated at the medical intensive care unit (ICU) in university-affiliated hospital from January 2005 to December 2006 were reviewed. Initiation of RRT was stratified into "early" and "late" by RIFLE (Risk, Injury, Failure, Loss, and End-stage) criteria and blood urea nitrogen (BUN) at the time RRT began. The primary outcome was death after 28 days from any cause. RESULTS: Of the 326 patients diagnosed with SSSS and admitted into the medical ICU during the study period, 78 patients received RRT. Mean age was 61.5 +/- 14.7 years old and 54 patients were male (69.2%). The initiation of RRT was categorized into early (Risk, and Injury) and late (Failure) by RIFLE criteria and also categorized into early (BUN < 75 mg/dl) and late (BUN > or = 75 mg/dl). When the relationship between RIFLE criteria and 28 day mortality was compared, no significant difference was shown (70.8% vs. 73.3%, p = 0.81). The initiation of RRT by BUN also showed no significant difference in 28 day mortality (77.3% vs. 69.6%, p = 0.50). CONCLUSIONS: Initiation of RRT, stratified into "early" and "late" by RIFLE and BUN, showed no significant difference in 28 day mortality regarding patient with SSSS.
