The Effect of Alpha-tocopherol Supplementation on the Improvement of Antioxidant Status and Lymphocyte DNA Damage in Postmenopausal Women.
- Author:
Chang Suk KIM
1
;
Hae Jin KANG
;
Soon Hee LEE
;
Yoo Kyoung PARK
;
Myung Hee KANG
Author Information
1. Department of Food & Nutrition, Daedeok Valley Campus, Hannam University, Daejeon 305-811, Korea. mhkang@hnu.kr
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
vitamin E supplementation;
antioxidant status;
lymphocyte DNA damage;
postmeDNA dam
- MeSH:
alpha-Tocopherol*;
Ascorbic Acid;
DNA Damage*;
DNA*;
Female;
gamma-Tocopherol;
Humans;
Lymphocytes*;
Plasma;
Vitamin E;
Vitamins
- From:The Korean Journal of Nutrition
2007;40(8):708-718
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of this project was to evaluate whether vitamin E supplementation could improve the antioxidant status and lymphocyte DNA damage in Korean postmenopausal women. This was double blinded, placebo-controlled trial. Thirty-five subject were randomized to receive either placebo 400 mg/capsule or natural alpha-tocopherol 400 IU/capsule, 2 times a day for 6 weeks. We measured plasma vitamin C, alpha-tocopherol, gamma-tocopherol, alpha-carotenoid, beta-carotenoid, lycopene concentration and tail length, %DNA in tail, tail moment in lymphocyte DNA damage index. Vitamin E supplementation group had significantly increased plasma vitamin C (p < 0.05), alpha-tocopherol (p < 0.000), whereas gamma-tocopherol (p < 0.000) and tail length (p < 0.05) were significantly decreased. However, placebo supplementation group also had significantly increased plasma vitamin C (p < 0.05). In conclusion, our study shows that vitamin E supplementation to Korean postmenopausal women may partially improve antioxidant status and lymphocyte DNA damage.
