Efficacy of Benzodiazepines to Laryngopharyngeal Reflux: A Double-Blind, Randomized Controlled Study.
- Author:
Kyung Hoon PARK
1
;
Bon Jo KOO
;
Jung June PARK
;
Sun Ki KIM
;
Sun Myung CHOI
;
Soon Uk KWON
;
Sang Won YOON
Author Information
1. Department of Otolaryngology, School of Medicine, Eulji University, Seoul, Korea. sm4329@hanafos.com
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Globus hystericus;
Gastroesophageal reflux;
Diazepam
- MeSH:
Anti-Anxiety Agents;
Benzodiazepines*;
Conversion Disorder;
Diazepam;
Gastroesophageal Reflux;
Humans;
Hydrogen-Ion Concentration;
Laryngopharyngeal Reflux*;
Proton Pump Inhibitors;
Somatoform Disorders
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2005;48(10):1267-1270
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Anti-anxiety drugs such as benzodiazepines are often given to globus patients in practice, based on the notion that globus is a kind of somatization disorder. However, many of globus are caused by laryngopharyngeal reflux (LPR) and the effects of anti-anxiety drugs to LPR are unknown. The study goal was to assess the efficacy of benzodiazepines to LPR. SUBJECTS AND METHOD: We selected 51 LPR patients, who were confirmed by 24-hour double-probe ambulatory pH monitoring. Patients were allocated into case and control groups at random and entered into a double-blind trial. Patients in the control group received proton pump inhibitors and prokinetics. Diazepam was added to patients in the case group. Assessments were made after 4 weeks of treatment using reflux symptom index (RSI) and reflux finding score (RFS). RESULTS: In both groups, RSI and RFS were improved significantly at the end of the study. However, there was no significant difference between the two groups. CONCLUSION: Diazepam seems to have little efficacy in the treatment of LPR.
