Effect of Cephalosporins on Growth Plates of Femoral Heads of Rats.
- Author:
Kyu Cheol SHIN
1
;
Dong Hyek KIM
;
Dong Heon KIM
;
Beob Yi LEE
Author Information
1. Department of Orthopedic Surgery, Kon-kuk University Medical College, Choong Joo, Korea.
- Publication Type:Original Article
- Keywords:
Rat;
Growth plate;
Rough endoplasmic reticuium;
Ceftezole Na
- MeSH:
Alcian Blue;
Animals;
Cephalosporins*;
Chondrocytes;
Dilatation;
Endoplasmic Reticulum, Rough;
Glycosaminoglycans;
Growth Plate*;
Head*;
Rats*
- From:The Journal of the Korean Orthopaedic Association
1999;34(2):351-356
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To study the effect of ceftezole Na on the matrix of femoral epiphyseal plates. MATERIALS AND METHODS: Rats were intraperitoneally injected with ceftezole Na (1500 mg/kg B.W) was every day for a week. The specimens obtained from the femoral head were stained with alcian blue (pH 2.5)-P.A.S. to detect the distribution of acid and neutral mucopolysaccharides, and ultrastructural studies for growth plates were also performed. RESULTS: We found that interterritorial and territorial matrices of treatment groups were weakly stained than that of control groups and dilatation and sacculation were observed in rough endoplasmic reticulums in the chondrocyte of the treated group. CONCLUSIONS: According to the histochemical and ultrastructural research, ceftezole Na induces a decrease in mucosubstances in the chondrocytes of growth plate.
