Alterations of the Apoptosis Genes and Their Products in Non-small Cell Lung Cancer Tissues.
- Author:
Nam Jin YOO
1
;
Sug Hyung LEE
Author Information
- Publication Type:Review
- Keywords: Non-small cell lung cancer; Apoptosis; Mutation; Expression
- MeSH: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Death
- From:Journal of Lung Cancer 2008;7(2):59-64
- CountryRepublic of Korea
- Language:Korean
- Abstract: Apoptosis is a principal type of cell death, and it has a profound effect on the development of cancer. It is also well known that anti-cancer agents induce apoptosis, and defects in the apoptosis pathways reduce the treatment sensitivity. Of the many pathways that induce apoptosis, the mechanisms of the intrinsic and extrinsic apoptosis pathways are well established. Non-small cell lung cancer (NSCLC) is a leading cause of cancer death worldwide, yet the exact molecular mechanisms of its development remain unclear. Apoptosis deregulations may underlie the development and pathogenesis of NSCLC. This review discusses the general mechanisms of apoptosis, the constituents of the apoptosis machinery and the alterations of the apoptosis-related genes in NSCLC
