Serum Immunoglobulins in Childrens with Recurrent Sinusitis.
- Author:
Hee Kyu KIM
1
;
Hyun Ho KIM
;
Hwa Ryung CHUNG
Author Information
1. Department of Otorhinolaryngology, Nowon Eulji Hospital, College of Medicine, Eulji University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Recurrent sinusitis;
Serum immunoglobulin;
Immunodeficiency
- MeSH:
Agglutination;
Child*;
Enzyme-Linked Immunosorbent Assay;
Humans;
Hypersensitivity;
IgA Deficiency;
Immunoassay;
Immunoglobulin G;
Immunoglobulin M;
Immunoglobulins*;
Latex;
Reference Values;
Sinusitis*
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
1997;40(12):1752-1756
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Sinusitis is a common and frequently recurrent illness in children. Respiratory allergy has been recognized as a major factor that predisposes children to recurrent and chronic sinusitis. Another important causative factors of recurrent sinusitis in children is immunodeficiency diseases. Among them, humoral immunodeficient disease especially is associated with recurrent sinusitis. Most common immune defect in recurrent sinusitis is immunoglobulin deficiency. OBJECTIVES: The aim of this study is to obtain a quantitative data of serum immunoglobulins in children with recurrent sinusitis, to investigate a relationship between recurrent sinusitis and immunoglobulin deficiency. MATERIALS AND METHODS: 30 childrens were selected who had been diagnosed as recurrent sinusitis at Nowon Eulji hospital in 1996. The serum immunoglobulins were evaluated by Latex agglutination immunoassay and ELISA. RESULTS: The serum IgG was within normal limits and IgA deficiency appeared in 1 patient but serum IgM appeared higher than normal value over 3 years patients. The serum IgG subclass deficiency appeared in 3 patients for IgG(1), 7 patients for IgG(2), 14 patients for IgG(3), 10 patients for IgG(4). The combined serum IgG subclass deficiency appeared in 4 patients for IgG(2) and IgG(3), 1 patient for IgG(2) and IgG(4), 4 patient for IgG(3) and IgG(4), 1 patient for IgG(1) and IgG(2) and IgG(3). CONCLUSION: Immunoglobulin deficiency is approved to be closely associated with recurrent sinusitis in children.
