Characteristic Clinical Behaviors of and Prognosis for Mucinous Adenocarcinomas in the Colon and Rectum.
- Author:
Yeun Sik YU
1
;
Hee Cheol KIM
;
Sang Jun PARK
;
Jang Hak YU
;
Jung Sun KIM
;
Gang Hong LEE
;
Chang Sik YU
;
Jin Cheon KIM
Author Information
1. Colorectal Clinic, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea. hckim@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Colorectal neoplasms;
Adenocarcinoma Mucinous;
Prognosis;
Survival rate
- MeSH:
Adenocarcinoma;
Adenocarcinoma, Mucinous*;
Appointments and Schedules;
Chungcheongnam-do;
Colon*;
Colorectal Neoplasms;
Diagnosis;
Follow-Up Studies;
Humans;
Mucins*;
Neoplasm Metastasis;
Prognosis*;
Rectum*;
Recurrence;
Retrospective Studies;
Survival Rate
- From:Journal of the Korean Society of Coloproctology
2003;19(6):379-385
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The clinical significance of a mucinous-type colorectal adenocarcinoma is still controversial. Mucinous colorectal adenocarcinomas have been suggested to have distinct clinicopathologic features, i.e., early-onset, right-side dominancy, and poor prognosis. We aimed to verify the biological behaviors of and survivals for mucinous adenocarcinomas compared with non-mucinous adenocarcinomas. METHODS: Using a database of colorectal cancers at Asan Medical Center between 1989 and 2000, we enrolled 121 mucinous adenocarcinoma and 2,289 non-mucinous adenocarcinoma patients in this study. Clinical, pathological characteristics of and prognoses for mucinous adenocarcinomas were analyzed and compared with those for non-mucinous adenocarcinomas, retrospectively. The median follow-up period was 24 (0~113) months for mucinous adenocarcinomas and 32 (0~130) months for non-mucinous adenocarcinoma. RESULTS: Compared to non-mucinous adenocarcinomas, mucinous adenocarcinomas showed distinctive clinicopathologic features of early-onset (P<0.001), frequent family history (P<0.001), right-side dominancy (P=0.010), advanced stage at diagnosis (P<0.001), and common peritoneal seeding at diagnosis (P<0.001). The recurrence rate in the mucinous adenocarcinoma group was 45.2% during the follow-up period: 21.6% distant metastasis, 14.3% peritoneal dissemination, 5.7% local recurrence, and 3.6% simultaneous local recurrence and distant metastasis. The five-year survival rates in stages II and III were 70% and 48.7%, respectively, for mucinous adenocarcinomas and 92% and 50.2%, respectively, for non-mucinous adenocarcinomas. This difference was statistically significant. CONCLUSIONS: Mucinous adenocarcinomas seem to have distinct biologic behaviors with different clinicopathologic features and poor prognosis. A surgical approach with a follow-up schedule considering the characteristics of mucinous adenocarcinomas is needed.
