Expression of Fos Protein in Brainstem Vestibular Nuclei of Rat - I. Off-axis Centripetal Acceleration -.
- Author:
Han Kyu SUH
1
;
Ho Jeong PARK
;
Hyun Ho LIM
;
Soon Jae HWANG
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Off-axis centripetal acceleration;
Fos protein;
Vestibular nuclei
- MeSH:
Acceleration*;
Animals;
Brain Stem*;
Genes, fos;
Neural Pathways;
Neurons;
Otolithic Membrane;
Rats*;
Vestibular Nuclei*
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
1997;40(2):286-291
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Fos, the protein product of c-fos gene, has been known to be rapidly expressed in neurons following various external and internal stimuli. This experiment was performed to determine whether off-axis centripetal acceleration cause a proper stimulation to the otolith organ and the afferent neural pathway from the otolith organ can be mapped by detection of expressed Fos protein. Therefore we performed on-axis and off-axis centripetal acceleration stimulation to experimental animals and investigated Fos expression immunohistochemically. In results, there were no expression of Fos protein following on-axis centripetal acceleration, whereas in the medial, descending vestibular nuclei and y-group of the off-axially stimulated animal, we could find strong expression of Fos protein.
