Increased Expressions of eNBC and NHE1 in Ischemic Penumbra after Permanent Middle Cerebral Artery Occlusion.
- Author:
Yong Wook JUNG
1
;
Jin Seo PARK
Author Information
1. Department of Anatomy, College of Medicine, Dongguk University, Kyungju 780-714, Korea. jungyw@dongguk.ac.kr
- Publication Type:Original Article
- Keywords:
Ischemia;
Penumbra;
eNBC;
NHE1
- MeSH:
Brain;
Infarction, Middle Cerebral Artery*;
Ischemia;
Middle Cerebral Artery*;
Models, Animal
- From:Korean Journal of Anatomy
2007;40(2):107-113
- CountryRepublic of Korea
- Language:English
-
Abstract:
We conducted a chronological and comparative analysis of the levels of the electrogenic Na+/HCO3-cotransporter (eNBC) and Na+/H+ exchanger 1 (NHE1) on ischemic penumbra, using the rat model of permanent middle cerebral artery occlusion (pMCAO). Both eNBC and NHE1 levels were significantly higher in the ischemic penumbra from 3 h to 6 h after focal ischemia than in the sham-operated control group. The enhancement of eNBC and NHE1 production following focal ischemia may contribute to brain cell swelling or damage during ischemic penumbra through intracellular alkalinization and Na+ overload. Therefore, increases of eNBC and NHE1 in ischemic penumbra may play an important role in secondary brain cell damages following permanent focal ischemic insults.
