Urinary Transforming Growth Factor-beta Induced Gene-h3 (betaig-h3)as a Marker of Lupus Activity in SLE with Nephritis.
- Author:
Il KIM
1
;
Cheol Ho HONG
;
Hyun Seok CHO
;
Sun Jin YOU
;
Chang Hee PAIK
;
Hye Soon LEE
;
Wan Sik UHM
;
Tae Hwan KIM
;
Jae Bum JUN
;
Dae Hyun YOO
;
Think You KIM
;
Chang Hwa LEE
;
Chong Myung KANG
;
Moon Hyang PARK
;
In San KIM
;
Sang Cheol BAE
Author Information
1. The Hospital for Rheumatic Diseases, Division of Nephrology, Hanyang University Medical Center, Korea. scbae@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
betaig-h3;
Lupus nephritis;
TGF-beta
- MeSH:
Biopsy;
Creatinine;
Humans;
Lupus Nephritis;
Necrosis;
Nephritis*;
Proteinuria;
Transforming Growth Factor beta
- From:The Journal of the Korean Rheumatism Association
2003;10(4):365-373
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: TGF-beta-induced gene-h3 (betaig-h3) is a novel gene induced by active TGF-beta and the association with other renal disease is reported. Lupus nephritis is characterized by excessive extracelluar matrix accumulation and the implication that TGF-beta is increased in lupus nephritis is known. We measured the urinary betaig-h3 in lupus nephritis and sought its association with the activity of lupus nephritis through renal biopsy. The objective of this study was to examine urinary betaig-h3 excretion in lupus nephritis and the association with activity of lupus nephritis. METHODS: Fifteen patients (median age 32.6 2.9 years, range 18~64) who developed lupus nephritis underwent renal biopsy. At the time of biopsy, they showed significant proteinuria. Total urinary betaig-h3 concentration was assayed by enzyme-linked immunoabsorbent assay and expressed as a ratio to urinary creatinine concentration. RESULTS: There were correlations between urinary betaig-h3 and the reduction of C3 (r= 0.566, p=0.028<0.05), the magnitude of proteinuria (r=0.531, p=0.042<0.05). The Activity Index, Chronicity Index in the renal biopsy, C4, anti-dsDNA Ab titer were not significantly correlated with urinary betaig-h3 excretion, but the patients with high Activity Index had the increased level of urinary betaig-h3. Five patients who had fibrinoid necrosis in renal biopsy showed higher level of urinary betaig-h3 than the others (107.78 43.02 vs. 50.21 10.12 ng/ ml, p=0.061) CONCLUSION: In this study, There is some correlation between urinary betaig-h3 and the activity of lupus nephritis. Urinary betaig-h3 may play a role in predicting the active lupus nephritis. A further study is needed in large population and in situ expression of betaig-h3.
