Demonstration of Eosinophil Cationic Protein in Pediatric Chronic Otitis Media with Effusion Associated with Allergy.
- Author:
Chul Ho JANG
1
Author Information
1. Department of Otolaryngology, Wonkwang Medical School, Iksan, Korea. chul@wonnms.wonkwang.ac.kr
- Publication Type:Original Article
- Keywords:
COME;
Allergy;
ECP
- MeSH:
Asthma;
Eosinophil Cationic Protein*;
Eosinophils*;
Humans;
Hypersensitivity*;
Otitis Media with Effusion*;
Otitis Media*;
Otitis*;
Rhinitis
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2000;43(7):689-692
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Allergy may play a role in pediatric chronic otitis media with effusion (COME). It is generally accepted that selective recruitment of eosinophils is important in the pathogenesis of the allergic rhinitis and asthma. Eosinophil cationic protein (ECP) is an identifiable mediator in additional target organs involved in allergic reactions. This study was designed to discover the relationship of ECP and positive allergy in persistent COME. MATERIALS AND METHODS: Twenty patients with persistent COME were evaluated for ECP. Fifteen of these patients were confirmed allergy positive by MAST (multiple allergosorbent test). ECP in the middle ear effusions were measured using FEIA (fluoro-enzyme-immunoassay). RESULTS: The ECP level was statistically higher in the positive MAST group than in the negative MAST group (p<0.01). CONCLUSION: There was a correlation between ECP from middle ear effusion indeed was correlate with the patient having allergy, as confirmed by MAST.
