A Case of Nonfunctioning Parathyroid Carcinoma.
- Author:
Eun Jae JUNG
1
;
Kyu Hwan SEO
;
Woong Sik KIM
;
Kwang Yoon JUNG
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Nonfunctioning parathyroid cancer;
Hyperparathyroidism
- MeSH:
Calcium;
Diagnosis;
Drug Therapy;
Hyperparathyroidism;
Hyperparathyroidism, Primary;
Neoplasm Metastasis;
Parathyroid Glands;
Parathyroid Hormone;
Parathyroid Neoplasms*
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2002;45(3):303-305
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Parathyroid carcinoma is an uncommon endocrine tumor. Its usual clinical presentation is that of primary hyperparathyroidism with elevated serum calcium and parathyroid hormone levels. Nonfunctioning carcinoma of the parathyroid gland with normal serum calcium levels is very rare and more aggressive. Histologically, the neoplastic cells may be of variable size and shape but are usually uniform and not too dissimilar from normal parathyroid cells. There is a general agreement that a diagnosis of carcinoma based on cytologic detail is unreliable, and local invasion and metastasis constitute the only reliable criteria of malignancy. In both functional and nonfunctional carcinoma, early surgery has proven to be the only curative treatment approach whereas both chemotherapy and radiation therapy fail to produce systemic or regional benefit when used alone. En bloc excision of primary lesion with removal of any involved structures should be performed. This paper is a case report of a nonfunctioning parathyroid carcinoma and a review of the literature.
