Genetic Susceptibilities of MCP-1 and CCR2 to the Risk for Korean Allergic Rhinitis Patients Using Polymorphism Study.
- Author:
Jae Hoon LEE
1
;
Tae Wook CHOI
;
Cha Kun OH
;
Su Yeob PARK
;
Sung Weon YOON
;
Gyung Jae OH
;
Jeong Joong KIM
Author Information
1. Department of Otolaryngology, College of Medicine, Wonkwang University, Iksan, Korea. coolnose@wmc.wonkwang.ac.kr
- Publication Type:Original Article
- Keywords:
MCP-1MCP-1;
CCR2;
Rhinitis;
allergic;
perennial;
Korea;
Polymorphism
- MeSH:
Alleles;
Genetic Predisposition to Disease*;
Genotype;
Humans;
Isoleucine;
Korea;
Monocytes;
Odds Ratio;
Receptors, CCR2;
Rhinitis*;
Valine
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2004;47(2):127-131
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: A biallelic A/G polymorphism in the Monocyte chemotactic protein (MCP) -1 at position -2518 has been found to affect the level of MCP-1 expression. To investigate if these polymorphisms in chemokine ligand and receptor genes are relevant for the development of allergic rhinitis, we investigated polymorphisms of MCP-1 and CC chemokine receptor 2 (CCR2) known as the receptor of MCP-1. MATERIALS AND METHOD: Blood samples for genetic analysis were obtained from 198 individuals with allergic rhinitis and from 278 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for MCP-1 -2518 A/G (A/G polymorphism in the MCP-1 at position -2518) and CCR2 V64I polymorphisms (replacement of valine by isoleucine in CCR2 64) was used for genotyping. RESULTS: There were no differences in the frequencies of the genotypes in the controls and patients (p>0.05). The frequencies of the MCP-1 G and CCR2 A alleles were not statistically different between controls and allergic rhinitis patients (p>0.05). The odds ratios (95% confidence interval) of MCP-1 G/G and CCR2 A/A genotypes for allergic rhinitis were not statistically significant, whereas, alleles frequencies of MCP-1 -2518G and CCR2 A of controls were various according to the ethnic background. CONCLUSION: Our result suggests MCP-1 -2518 A/G and CCR2 V64I polymorphisms are not part of the factors contributing to genetical susceptibility in the development of allergic rhinitis in Koreans.
