Clinical Characteristics of Multifocal Papillary Thyroid Carcinoma.
10.3342/kjorl-hns.2009.52.6.512
- Author:
Jong Kil LEE
1
;
Duk Gyu LEE
;
Jin Choon LEE
;
Byung Joo LEE
;
Soo Geun WANG
;
Seok Man SON
;
In Ju KIM
;
Yong Ki KIM
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine, Busan, Korea. voicelee@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
Papillary thyroid cancer;
Multifocal;
Metastasis;
Lymphatic
- MeSH:
Carcinoma;
Carcinoma, Papillary;
Factor IX;
Female;
Humans;
Lymph Node Excision;
Lymph Nodes;
Male;
Neck;
Neck Dissection;
Neoplasm Metastasis;
Recurrence;
Retrospective Studies;
Sex Factors;
Thyroid Gland;
Thyroid Neoplasms;
Thyroidectomy
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2009;52(6):512-515
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Papillary thyroid cancers (PTCs) often present as multifocal tumors. Whether multifocal tumors are associated with increased risk of recurrence and mortality is still the subject of controversy. The aim of current study was to individualize factors associated with multifocality of papillary thyroid cancer and determine the clinical significance of multifocal thyroid cancer. SUBJECTS AND METHOD: We undertook a retrospective study of 403 patients treated between January, 2003 and June, 2007 for papillary thyroid carcinoma by total thyroidectomy and central compartment neck dissection (n=403) with or without comprehensive lateral neck dissection. There were 342 women and 61 men whose mean age was 47.3 years old. Following criteria were used to study the pattern of and factors related with multifocality : sex, age, extracapsular extension, central compartment lymph node metastasis, the involvement of lateral neck lymph node, AMES risk group, distant metastasis. RESULTS: Of those factors, sex (p=0.0481), central compartment lymph node metastasis (p=0.0007), the involvement of lateral neck lymph node (p=0.0001) were significantly related factors for multifocality of papillary thyroid cancer. Age, primary tumor size, AMES risk group were not significantly related with multifocality. Bilateral or contralateral central compartment lymph node metastasis occurred more frequently in multifocal PTCs (64.0%) than solitary PTCs (46.9)(p=0.012). CONCLUSION: Our data suggest that the multifocal tumors in patients with papillary thyroid carcinoma are associated with increased risk of bilateral central compartment and lateral cervical lymph node metastasis. Therefore, total thyroidectomy and bilateral central compartment lymph node dissection should be recommended as a routine procedure in multifocal papillary carcinoma
