Impact of early coronary angiography on the survival to discharge after out-of-hospital cardiac arrest.
- Author:
Jikyoung SHIN
1
;
Eunsil KO
;
Won Chul CHA
;
Tae Rim LEE
;
Hee YOON
;
Sung Yeon HWANG
;
Tae Gun SHIN
;
Min Seob SIM
;
Ik Joon JO
;
Keun Jeong SONG
;
Joong Eui RHEE
;
Yeon Kwon JEONG
;
Jin Ho CHOI
Author Information
- Publication Type:Multicenter Study ; Original Article
- Keywords: Early coronary angiography; Out-of-hospital cardiac arrest; Survival rate; Neurologic outcome
- MeSH: Cardiopulmonary Resuscitation; Coronary Angiography*; Coronary Artery Disease; Emergency Service, Hospital; Humans; Male; Myocardial Infarction; Out-of-Hospital Cardiac Arrest*; Prognosis; Survival Rate; Survivors
- From: Clinical and Experimental Emergency Medicine 2017;4(2):65-72
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: Acute myocardial infarction is a major cause of out-of-hospital cardiac arrest (OHCA). Coronary angiography (CAG) enables diagnostic confirmation of coronary artery disease and subsequent revascularization, which might improve the prognosis of OHCA survivors. Non-randomized data has shown a favorable impact of CAG on prognosis for this population. However, the optimal timing of CAG has been debated. METHODS: The clinical outcomes of 607 OHCA patients registered in CAPTURES (Cardiac Arrest Pursuit Trial with Unique Registration and Epidemiologic Surveillance), a nationwide multicenter registry performed in 27 hospitals, were analyzed. Early CAG was defined as CAG performed within 24 hours of emergency department admission. The primary outcome was survival to discharge, with neurologically favorable status defined by cerebral performance category scores ≤2. RESULTS: Compared to patients without CAG (n=469), patients who underwent early CAG (n=138) were younger, more likely to be male, and more likely to have received bystander cardiopulmonary resuscitation, pre-hospital defibrillation, and revascularization (P<0.01 for all). Analysis of 115 propensity score-matched pairs showed that early CAG is associated with a 2.3-fold increase in survival to discharge with neurologically favorable status (P<0.001, all). Survival to discharge increased consistently according to the time interval between emergency department visit and CAG (P<0.05). CONCLUSION: Early CAG of OHCA patients was associated with better survival and favorable neurologic outcomes at discharge. However, there was no clear time threshold for CAG that predicted survival to discharge.
