The Effects of Soybean Diet on the Diabetic Neuropathy in the Rats.
- Author:
Jeong Hee CHO
1
;
Soo Kyung AHN
;
Seung Min KIM
;
Won Taek LEE
;
Kyung Ah PARK
Author Information
1. Department of Neurology, National Health Insurance Corporation Ilsan Hospital, Korea.
- Publication Type:Original Article
- Keywords:
Diabetic neuropathy;
Soybean;
Streptozotocin;
Electron microscopy;
Myelinated nerve;
Unmyelinated nerve;
Morphologic Quantitative study
- MeSH:
Animals;
Atrophy;
Axons;
Diabetes Mellitus;
Diabetic Neuropathies*;
Diet*;
Glucose;
Humans;
Insulin;
Male;
Microscopy, Electron;
Mortality;
Nerve Fibers;
Nerve Fibers, Myelinated;
Rats*;
Rats, Sprague-Dawley;
Soybeans*;
Streptozocin;
Wallerian Degeneration
- From:Korean Journal of Anatomy
2006;39(6):433-441
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Neuropathy is a serious and disabling complication that contributes to increased morbidity and mortality in diabetic patients. There is progressive distal to proximal axonal atrophy that ultimately leads to Wallerian degeneration. This study was performed to identify the effect of soy bean on diabetic neuropathy using morphometry. Male Sprague-Dawley rats were grouped into control, diabetic with red chow diet and diabetic with soy bean diet. The myelinated nerve fibers were counted and fiber size distributions were evaluated in each group at 4 and 8 weeks, respectively. Diabetic neuropathy didn't develop in streptozotocin-induced diabetic rats at four weeks. At 8 weeks, the myelinated nerve fiber in diabetic with soy bean diet was larger in number than that in diabetic to which did not be administered insulin. The number of myelinated nerve fiber was not different between diabetic group with insulin and without insulin. Mean myelinated nerve fiber size was smaller in diabetic with soy bean diet than diabetic with red chow diet and control. Histogram of fiber size distribution was shifted to left in diabetic with red chow and soy bean diet groups compared to control. Light and electron microscopic findings showed marked degeneration of nerve fibers in diabetic with red chow diet but preservation in diabetic with soy bean diet. The level of glucose and HbA1c was lower in diabetic with soy bean diet than red chow diet. Soy bean could be effective in the protection of neuropathy induced by diabetes mellitus.
