Gene Expression of NeuroD/BETA2 during Development of the Mouse Central Nervous System.
- Author:
Jang Hyeon CHO
1
;
Woo Sup HWANG
;
Yeon Soo KIM
;
Young Don LEE
;
Haeyoung SUH-KIM
Author Information
1. Department of Anatomy, School of Medicine, Ajou University, Suwon 442-749, Korea.
- Publication Type:Original Article
- Keywords:
NeuroD;
BETA2;
brain;
mouse
- MeSH:
Adult;
Animals;
Brain;
Central Nervous System*;
Cerebellum;
Cerebrum;
Embryonic Development;
Female;
Gene Expression*;
Hippocampus;
Humans;
In Situ Hybridization;
Mice*;
Nervous System;
Neurogenesis;
Pregnancy;
Transcription Factors
- From:Korean Journal of Anatomy
2000;33(1):13-20
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
NeuroD/BETA2, a basic helix-loop-helix transcription factor, has been known to play a role in terminal differentia-tion during neurogenesis. To gain further insight into the function of NeuroD/BETA2 in the nervous system devel-opment, we examined the expression pattern of NeuroD/BETA2 during embryonic and postnatal development by in situ hybridization. Dynamic changes of NeuroD/BETA2 expression were observed in the developing nervous system. Gene expression of the NeuroD/BETA2 in developing cerebellum and hippocampus increased during the embryonic stages and persisted throughout postnatal development and remained at a stable level in the adult brain. NeuroD/ BETA2 expression was detected in postmitotic cells in the subventricular zone of the cerebrum during embryogenesis. This observation confirms that NeuroD/BETA2 may have a role in terminal differentiation during neurogenesis.
