Effect of Calcium and Activated Vitamin D ( 1- hydroxyvitamin-D ) on Bone Mineral Density in Osteoporosis.
- Author:
Jun Seop JAHNG
;
Jin Oh PARK
- Publication Type:Original Article
- Keywords:
osteoporosis;
calcium;
activated vitamin D
- MeSH:
Aged;
Bone Density*;
Calcium*;
Female;
Humans;
Hypercalcemia;
Hypercalciuria;
Korea;
Osteoporosis*;
Vitamin D*;
Vitamins*
- From:The Journal of the Korean Orthopaedic Association
1997;32(4):846-852
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Forty-five elderly female osteoporotics were given daily dose of 750 mg of calcium and 1.0 microgram of activated vitamin D (1-a hydroxyvitamin D) orally for 24 months to evaluated the effect of drugs on bone mineral density. Bone mineral density was evaluated and repeated every 6 months for 2 years. Average bone mineral density (L (2)-L (4)) and T score were 0.773 (SD 0.120) and -2.90 (SD 0.97) before treatment, and increased to 0.808 (SD 0.121) and -2.59 (SD 0.97) after 24 months of therapy, respectively (p<0.01). During treatment, complications including hypercalcemia, hypercalciuria, or renal stone were not observed, and indicators of renal function were normal. Therefore the activated vitamin D treatment in osteoporosis is effective in diminishing normal decline of bone mineral density, especially in areas with low calcium and vitamin D intake, such as South Korea.
