Effect of Cyanidin on Cell Motility and Invasion in MDA-MB-231 Human Breast Cancer Cells.
- Author:
Su Kyoung CHU
1
;
Eun Young SEO
;
Woo Kyoung KIM
;
Nam E KANG
Author Information
1. Department of Nursing, Eulji University, Seongnam 461-713, Korea.
- Publication Type:Original Article
- Keywords:
cyanidin;
metastasis;
motility;
invasion;
breast cancer
- MeSH:
Anthocyanins;
Apoptosis;
Breast;
Breast Neoplasms;
Cell Line;
Cell Movement;
Humans;
Neoplasm Metastasis;
RNA, Messenger
- From:The Korean Journal of Nutrition
2008;41(8):711-717
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anthocyanidins, the aglycones of anthocyanins, are natural colorants belonging to the flavonoid family. Cyanidin is one of the anthocyanidins, used for their antioxidant properties. Furthermore, previous studies have shown anthocyanidin-rich material extracts or aglycone form inhibit growth and induce apoptosis of cancer cells. But, Tumor metastasis is the most important cause of cancer death, and various treatment strategies have targeted on preventing the occurrence of metastasis. This study investigated the effects of cyanidin on metastasis processes, including motility, invasion and activity of MMP-2 and MMP-9 in MDA-MB-231 human breast cancer cell lines. We cultured MDA-MB-231 cells in presence of various concentrations 0, 5, 10 and 20 micrometer of cyanidin. The cell motility was significantly decreased dosedependently in cells treated with cyanidin (p < 0.05) and cyanidin treatment caused the significant suppression of the invasion (p < 0.05). MMP-2 and MMP-9 activities, and MMP-9 mRNA express were not affected by anthocyanin treatment. In conclusion, cyanidin inhibits cell motility, invasion in MDA-MB-231 human breast cancer cell lines.
