Association between Plasma Tocopherol Levels and Related Factors in Middle-Aged Korean Men.
- Author:
Kyung Ja KIM
1
;
Hye Jin LEE
;
Yoo Kyoung PARK
;
Myung Hee KANG
Author Information
1. Department of Food and Nutrition, Hannam University, Daejeon 306-791, Korea. mhkang@hannam.ac.kr
- Publication Type:Original Article
- Keywords:
vitamin E;
alpha-tocopherol;
gamma-tocopherol;
plasma lipid;
smoking;
drinking;
diet;
DNA damage
- MeSH:
Adult;
alpha-Tocopherol;
Catalase;
Cholesterol;
Cholesterol, LDL;
Chronic Disease;
Diet;
DNA Damage;
Drinking;
Erythrocytes;
gamma-Tocopherol;
Humans;
Life Style;
Lymphocytes;
Male;
Oxidative Stress;
Plasma*;
Smoke;
Smoking;
Superoxide Dismutase;
Tocopherols*;
Triglycerides;
Vitamin E;
Vitamins
- From:The Korean Journal of Nutrition
2006;39(8):773-785
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Vitamin E in the body system plays an important role in preventing chronic diseases by decreasing the oxidative stress by free-radicals. However, there are not enough researches on analyzing the primary factors affecting vitamin E levels in the blood in Korean adults. Therefore, the purpose of this research was to examine blood tocopherol levels and the primary factors affecting the status. A complete lifestyle survey was performed on 314 Korean adult men and surveyed their smoking, drinking and exercising habits. The average plasma level of alpha- and gamma-tocopherol showed similar mutual relations with plasma total cholesterol (TC), triglyceride (TG), or low density lipoprotein cholesterol (LDL-C) levels (p < 0.001). Plasma alpha-tocopherol level of the subjects did not show any difference as smoking, drinking and exercising habits changed. However, gamma-tocopherol per TG showed much lower figure in smokers than non smokers (p < 0.05). Amongst diet factors, plasma alpha-tocopherol level showed negative correlations with Vitamin E intake, while gamma-tocopherol level showed positive correlations with Vitamin E intake. Erythrocyte superoxide dismutase (SOD) activity and plasma tocopherol showed negative correlations, and catalase activity and plasma alpha-tocopherol showed positive correlationship. The level of cell DNA damage of lymphocyte and plasma alpha- or gamma-tocopherol showed negative correlations. As a result of this research, the factors that affect Korean adult men's plasma alpha-tocopherol level are plasma TG, LDL-C and cell DNA damage in lymphocyte, while the factors that affect gamma-tocopherol level are plasma TG, LDL-C and vitamin E intake based on multiple regression analysis. These findings implies that the level of different types of tocopherol depends on slightly different factors. A further research is needed on the factors involved in the differentiation of the types of tocopherol.
