Photodynamic Therapy(PDT) for Early Glottic Cancer which was Recurred after Initial Treatment Modality.
- Author:
Phil Sang CHUNG
1
;
Jeong Hwan MOON
;
Euteum PARK
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Dankook University College of Medicine, Cheonan, Korea. pschung@dankook.ac.kr
- Publication Type:Case Report
- Keywords:
Laryngeal neoplasm;
Photodynamic therapy;
Photosensitizer
- MeSH:
Debridement;
Follow-Up Studies;
Humans;
Hyperbaric Oxygenation;
Laryngeal Neoplasms;
Laryngectomy;
Lasers, Semiconductor;
Photochemotherapy;
Recurrence;
Vocal Cords;
Voice Quality
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2006;49(4):468-471
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Photodynamic therapy (PDT) is a method used to treat cancer early by irradiating laser with suitable wavelength after injection of a photosensitizer. We introduce the result of PDT for treating an early glottic cancer where initial treatment modality had failed. We tried PDT for 2 patients: one had recurrence after laser cordectomy (T1b) and the other after radiation therapy (T2). Photogem 2 mg/kg was injected intravenously and laser irradiation was performed after 48 hours. We irradiated the lesion site using diode laser (630 nm) delivered through 5 mm cylindrical fiber tip. The energy density, as determined by the depth and site of the lesion, were 138 J/cm and 204 J/cm, respectively. Patient with T1b is alive with no evidence of disease for 46 months post-PDT follow up. Patient with T2 developed chondritis at the subglottis but improved after hyperbaric oxygen therapy and several surgical debridement. After 4 months, tumor recurred at both vocal folds and was managed with total laryngectomy. PDT is a new treatment modality with advantages of good voice quality, short period of admission, and less rate of morbidity and may be another useful salvage option.
