A Immunohistochemical Analysis of Collagen of Transverse Carpal Ligament in Patients with Carpal Tunnel Syndrome.
- Author:
Yong Jin CHUNG
1
;
Goo Hyun BAEK
;
Moon Sang CHUNG
;
Woo Dong NAM
;
Young Ho LEE
;
Chung Hoon LEE
;
Dong Yeon LEE
;
Hyuk Soo HAN
Author Information
1. Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Carpal tunnel syndrome;
Transverse carpal ligament;
Immunohistochemical staining;
Collagen types
- MeSH:
Carpal Tunnel Syndrome*;
Collagen Type I;
Collagen Type III;
Collagen*;
Humans;
Ligaments*
- From:The Journal of the Korean Orthopaedic Association
2001;36(6):607-611
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of this study was to determine differences in the specific collagen types of the transverse carpal ligament (TCL) in patients with carpal tunnel syndrome (CTS) and a control group without CTS. MATERIALS AND METHODS: Surgical specimens from 19 dissected TCLs in patients with idiopathic CTS and 5 controls without CTS were taken (1x1 cm2). We analyzed the manifestations of collagen types I and III by immunohistochemical staining. RESULTS: We found a homogeneous manifestation of type I and III collagens in the control group. However, in CTS patients, type III collagen was sporadically found around the perivascular and pericellular area, and type I collagen showed no definite differences between the two groups. The cellularity in CTS patients was much lower than that in the control group. CONCLUSION: The TCL in CTS patients shows reduced manifestation of type III collagen and less cellularity. These intrinsic changes may play a role in the different manifestations of collagen types in TCL.
