Voice Characteristics of Adductor Spasmodic Dysphonia before and after Botulinum Toxin-A Injection.
10.3342/kjorl-hns.2011.54.2.148
- Author:
Boram YUN
1
;
Hyang Hee KIM
;
Yaelin CHOI
;
Hong Shik CHOI
Author Information
1. Department of Otorhinolaryngology, Institute of Logopedics and Phoniatrics, Yonsei University College of Medicine, Seoul, Korea. hschoi@yuhs.ac
- Publication Type:Original Article
- Keywords:
Spasmodic dysphonia;
Botulinum toxin;
Voice assessment
- MeSH:
Botulinum Toxins;
Botulinum Toxins, Type A;
Dysphonia;
Equidae;
Female;
Humans;
Korea;
Ovum;
Phonation;
Quality of Life;
Self-Assessment;
Treatment Outcome;
Voice
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2011;54(2):148-153
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Botulinum toxin type A (BTX-A) injection is well known for its effectiveness in the treatment of "Spasmodic dysphonia". However, studies on the efficacy of BTX-A injection have not been attempted in Korea. Therefore, this study was carried out to investigate the effects of BTX-A. SUBJECTS AND METHOD: The study examined 12 female patients with 'adductor spasmodic dysphonia'. Objective assesments included aerodynamic analysis and electoroglottography (EGG) of each patient before and after BTX-A. Subjective assessments included using the Korean-version of Voice Handicap Index-30 (KVHI-30) and a patient self-rating scale. RESULTS: Aerodynamic analysis revealed that only maximum phonation time (MPT) was significantly shortened after the injection of BTX-A (p<0.05). In the EGG, the mean frequency distribution was significantly increased, while the mean amplitude and the mean closed quotient distribution were significantly decreased (p<0.05). The KVHI-30 and patient self-rating scale scores were significantly decreased (p<0.01) as well, demonstrating the effects of BTX-A on the quality of life. CONCLUSION: Our results show the effects of BTX-A objectively by comparing voice characteristics, which were measured through EGG before and after BTX-A injection, as well as by determining aerodynamic characteristics. The subjective self-assessment on the quality of life is significant as it may serve as a clinically relevant measure. This study may be helpful in elucidating treatment efficacy of BTX-A in many ways.
