Effects of the Mixture of Vitamin C, Vitamin E, Pycnogenol and Evening Primrose Oil on the UV-Induced Pigmentation and Wrinkle Reductions in Human Skin.
10.4163/kjn.2009.42.6.516
- Author:
Min Youl CHANG
1
;
Sang Ki PARK
;
Taek Jong KWAK
;
Hyoung Kook PARK
;
Cheon Koo LEE
;
Heon Sik LEE
;
Sun Yung LY
;
Seong Jin KIM
Author Information
1. LG Household & Healthcare Research Park, Daejeon 305-343, Korea.
- Publication Type:Original Article
- Keywords:
pycnogenol;
ultraviolet light induced pigmentation;
wrinkle reduction
- MeSH:
Administration, Oral;
Arm;
Ascorbic Acid;
Capsules;
Dietary Supplements;
Flavonoids;
Foot;
gamma-Linolenic Acid;
Humans;
Linoleic Acids;
Oenothera biennis;
Pigmentation;
Plant Oils;
Skin;
Skin Pigmentation;
Ultraviolet Rays;
Vitamin E;
Vitamins
- From:The Korean Journal of Nutrition
2009;42(6):516-522
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In this study, the effects of a mixture consisting of vitamin E, vitamin C, pycnogenol and evening primrose oil (mixture LGNC-5) on ultraviolet light (UV) induced pigmentation and wrinkle reductions of normal healthy volunteers were studied. In a double-blind placebo-controlled study, each of 54 subjects took daily either 4 capsules of the mixture LGNC-5 (Group ABC; 282.5 mg/capsule) or placebo (Group Ganada). We irradiated 2.5 MED UV on the upper arms and measured the whitening effect by colorimeter-based L value. The level of wrinkle reduction was determined by image analysis using skin replica around the crow' feet, and the level of serum vitamin E was determined at baseline and 12 weeks. After 12-week oral administration, the treated group showed a significant reduction in skin pigmentation and wrinkles compared with the placebo group (p = 0.011 and p = 0.000005 , respectively). Also, the level of serum vitamin E was significantly increased in the treated group after 12-week oral adminstration of the mixture compared with that in the placebo group (p = 0.0001). In conclusion, 12-week oral administration of LGNC-5 as a dietary supplement could be effective to reduce both UV induced pigmentation and skin wrinkle without side effects.
