The Transforming Growth Factor-beta1 Expression in Normal Laryngeal Mucosa, Laryngeal Dysplasia and Laryngeal Carcinoma.
- Author:
Young Wan JIN
1
;
Dong Yeup LEE
;
Chang Il CHA
;
Sang Hoon PARK
;
Nam Pyo HONG
;
Hwoe Young AHN
Author Information
1. Department of Otolaryngology, College of Medicine, Kyunghee University, Seoul, Korea. enthn@unitel.co.kr
- Publication Type:Original Article
- Keywords:
Transforming growth factor-beta1;
Neoplastic progression;
Laryngeal carcinoma
- MeSH:
Humans;
Laryngeal Mucosa*;
Larynx;
Transforming Growth Factor beta;
Transforming Growth Factor beta1
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
1999;42(4):478-482
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Transforming growth factor-beta1 (TGF-beta1) is a multifunctional regulator of cellular differentiation, motility and growth. Loss of sensitivity to the growth inhibitory effects by TGF-beta1 plays important roles in neoplastic progression. So expression of TGF-beta1 has been described in several tumors, but little is known about the role of TGF-beta1 in neoplastic progression of human larynx. The aim of this study was to investigate the role of TGF-beta1 in the neoplastic progression of human larynx. MATERIALS AND METHODS: We evaluated the expression of TGF-beta1 using immunohistochemical study in 6 cases of normal laryngeal mucosa, 6 cases of laryngeal dysplasia, 20 cases of laryngeal carcinoma. RESULTS: The results were as follows: 1) Normal laryngeal mucosa has no expression of TGF-beta1. 2) The expression of TGF-beta was 16.7% in laryngeal dysplasia, 50.0% in laryngeal carcinoma. CONCLUSION: The TGF-beta1 expression rate was correlated to the progression of laryngeal lesions when compared to normal laryngeal mucosa, laryngeal dysplasia and laryngeal carcinoma.
