Gadoxetic Acid (Gd-EOB-DTPA)-Enhanced MRI versus Gadobenate Dimeglumine (Gd-BOPTA)-Enhanced MRI for Preoperatively Detecting Hepatocellular Carcinoma: an Initial Experience.
10.3348/kjr.2010.11.4.433
- Author:
Yulri PARK
1
;
Seong Hyun KIM
;
Seung Hoon KIM
;
Yong Hwan JEON
;
Jongmee LEE
;
Min Ju KIM
;
Dongil CHOI
;
Won Jae LEE
;
Heejung KIM
;
Ji Hyun KOO
;
Hyo Keun LIM
Author Information
1. Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea. kshyun@skku.edu
- Publication Type:Original Article ; Comparative Study
- Keywords:
Hepatocellular carcinoma (HCC);
Gadoxetic acid-enhanced MRI;
Gadobenate dimeglumine-enhanced MRI
- MeSH:
Adult;
Aged;
Carcinoma, Hepatocellular/*diagnosis;
Female;
Gadolinium DTPA/*diagnostic use;
Humans;
Image Interpretation, Computer-Assisted;
Liver Neoplasms/*diagnosis;
Magnetic Resonance Imaging/*methods;
Male;
Meglumine/*analogs & derivatives/diagnostic use;
Middle Aged;
Organometallic Compounds/*diagnostic use;
Predictive Value of Tests;
ROC Curve;
Sensitivity and Specificity;
Statistics, Nonparametric
- From:Korean Journal of Radiology
2010;11(4):433-440
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: This study was designed to compare the diagnostic performance of gadoxetic acid-enhanced magnetic resonance imaging (MRI) with gadobenate dimeglumine-enhanced MRI for preoperatively detecting hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Eighteen consecutive patients (17 men and one woman, age range: 31-73 years) with 22 HCCs underwent examinations with gadoxetic acid enhanced MRI and gadobenate dimeglumine-enhanced MRI on a 3.0-Tesla unit. The diagnosis of HCC was established after surgical resection and pathological conformation. Three observers independently reviewed each MR image in a random order on a tumor-by-tumor basis. The diagnostic accuracy of these techniques for the detection of HCC was assessed by performing an alternative free-response receiver operating characteristic (ROC) analysis. The sensitivity and positive predictive values were evaluated. RESULTS: The average value of the area under the ROC curve (Az) for gadoxetic acid enhanced MRI (0.887) was not significantly different from the Az (0.899) for gadobenate dimeglumine-enhanced MRI (p > 0.05). The overall sensitivities of gadoxetic acid enhanced MRI and gadobenate dimeglumine-enhanced MRI were 80% and 83%, respectively, with no significant difference (p > 0.05). The differences of the positive predictive values for the two contrast agents for each observer were not statistically significant (p > 0.05). CONCLUSION: The diagnostic performance of gadoxetic acid-enhanced MRI and gadobenate dimeglumine-enhanced MRI for preoperatively detecting HCC is quite similar.
