The Effect of Isoflavone and Gamma-linolenic Acid Supplementation on Serum Lipids and Menopausal Symptoms in Postmenopausal Women.
10.4163/kjn.2010.43.2.123
- Author:
Jung Hyun GWAK
1
;
Ji Young KIM
;
Hyae Jin KIM
;
Dong Hyeok SHIN
;
Jong Ho LEE
Author Information
1. Interdisciplinary Program: Science for Aging, Yonsei University, Seoul 120-749, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
isoflavone;
gamma-linolenic acid;
menopausal symptoms;
serum lipids;
postmenopausal women
- MeSH:
Apolipoprotein A-I;
Cholesterol, HDL;
Cholesterol, LDL;
Female;
gamma-Linolenic Acid;
Humans;
Lipid Peroxides;
Lipoproteins, LDL;
Oxidative Stress;
Plasma
- From:The Korean Journal of Nutrition
2010;43(2):123-131
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was performed to examine the combined effects of gamma linolenic acid and isoflavone supplementation on menopausal symptoms and serum lipids in 73 postmenopausal women. A total subjects were randomly assigned to isoflavone (30 mg) + gamma-linolenic acid (110 mg) group or placebo group. We measured menopausal symptoms by modified Kupperman Index (KI) and oxidized LDL, lipid peroxides, blood components and anthropometric parameters before and after the 12 week intervention period. After the 12 weeks of supplementation, supplement group and placebo group showed a significant reduction of modified kupperman index (p < 0.001). Isoflavone (30 mg) + gamma-linolenic acid (110 mg) supplement group showed a significant reduction of oxidized LDL cholesterol concentration (p = 0.006) whereas placebo group did not show significant change. Isoflavone and gamma-linolenic acid consumption did not significantly affect plasma concentrations of total, LDL, HDL cholesterol, triglyceride, apo A1, B and blood components. The result of present study demonstrated the supplementation of 30 mg isoflavone and 110 mg gamma-linolenic acid per day for 12 weeks may protect LDL cholesterol from oxidative stress.
