Immunocytochemical Localization of GABA Transporter-3 in the Guinea Pig Retina.
- Author:
Eun Jin LEE
1
;
Su Ja OH
;
Jin Woong CHUNG
;
Myung Hoon CHUN
Author Information
1. Department of Anatomy, College of Medicine, The Catholic University of Korea, 505 Banpo-Dong, Socho-Ku, Seoul, Korea. mhchun@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
GABA transporter-3;
GAD-65;
CD15;
Amacrine cells;
Immunocytochemistry;
Retina;
Guinea pig
- MeSH:
Amacrine Cells;
Animals;
gamma-Aminobutyric Acid*;
Ganglion Cysts;
Guinea Pigs*;
Guinea*;
Immune Sera;
Immunohistochemistry;
Retina*
- From:Korean Journal of Anatomy
2002;35(2):173-177
- CountryRepublic of Korea
- Language:English
-
Abstract:
The cellular localization of the GABA transporter-3 (GAT-3) was examined in the guinea pig retina by immunocytochemistry, using antisera against GAT-3. GAT-3 immunoreactivity was localized to cell bodies in the inner nuclear layer, and labeled processes were densely distributed in the inner plexiform layer (IPL) close to the ganglion cell layer. All GAT-3 labeled cells exhibited GAD65 immunoreactivity. In addition, 67% of GAT-3 labeled amacrine cells showed carbohydrate epitope CD15 immunoreactivity. These results indicate that GAT-3 is involved in modulating the rod pathway in the IPL of the guinea pig retina via presumptive A17 amacrine cells.
