Tissue distribution of sialic acid-linked influenza virus receptors in beagle dogs.
10.4142/jvs.2012.13.3.219
- Author:
Zhang Yong NING
1
;
Xin Tao WU
;
Yan Fen CHENG
;
Wen Bao QI
;
Yu Fu AN
;
Heng WANG
;
Gui Hong ZHANG
;
Shou Jun LI
Author Information
1. College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. guihongzh@scau.edu.cn
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
dogs;
influenza virus receptors;
lectin;
sialic acid
- MeSH:
Animals;
Dog Diseases/metabolism;
Dogs/metabolism/*virology;
Female;
Influenza A Virus, H5N1 Subtype/*metabolism;
Maackia/chemistry;
Male;
N-Acetylneuraminic Acid/metabolism;
Organ Specificity;
Orthomyxoviridae Infections/metabolism/transmission/veterinary;
Plant Lectins/metabolism;
Receptors, Cell Surface/analysis/chemistry/metabolism;
Receptors, Virus/analysis/chemistry/*metabolism;
Sambucus nigra/chemistry
- From:Journal of Veterinary Science
2012;13(3):219-222
- CountryRepublic of Korea
- Language:English
-
Abstract:
Reports of influenza A virus infections in dogs has received considerable attention from veterinarians, virologists, and epidemiologists. Interaction between influenza viral hemagglutinin and cell oligosaccharides containing sialic acid residues results in infection. Sialic acids have an alpha-2,3-linkage to the penultimate galactose in the avian influenza virus receptor and an alpha-2,6-linkage in the human receptor. To date, there are no detailed data on the tissue distribution or histological features of either type of sialic acid-linked influenza virus receptors in beagle dogs, which are common laboratory animals and pets. We conducted the current study to visualize the in situ tissue distribution of both sialic acid-linked influenza virus receptors in various organs of beagle dogs using Maackia amurensis lectin II and Sambucus nigra agglutinin. Both alpha-2,3- and alpha-2,6-sialic acid-linked receptors were detected in the endothelial cells of the respiratory tract and other organs. Endothelial cells of most gastrointestinal organs were negative for alpha-2,3-sialic acid-linked receptors in the dogs. Our results suggested that these canine organs may be affected by influenza virus infection. The findings from our study will also help evaluate the occurrence and development of influenza virus infections in dogs.
