GUARDIX-SL(R) in Sinus Surgery: A Preclinical Animal Study.
- Author:
Chan Kee YOO
1
;
Chang Ho LEE
;
Chang Woo KANG
;
Kon Ik LEE
;
Kye Youn RO
;
Ji Yeon CHOI
;
Seok Chan HONG
;
Chol CHANG
;
Young Woo LEE
;
Young Moo LEE
;
Jin Hong KIM
Author Information
1. Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Pochon CHA University, Seongnam, Korea. davidaa@kornet.net
- Publication Type:Original Article
- Keywords:
Sodium hyaluronate;
Sodium carboxymethylcellulose;
Stenosis;
Adhesions
- MeSH:
Animals*;
Carboxymethylcellulose Sodium;
Constriction, Pathologic;
Gelatin Sponge, Absorbable;
Hyaluronic Acid;
Maxillary Sinus;
Models, Animal;
Rabbits;
Wound Healing
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2005;48(12):1457-1461
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: The most frequent complication of FESS (functional endoscopic sinus surgery) is stenosis of the operation site. The complication may influence the postoperative wound healing and the outcome of surgery. There are several measures proposed to prevent the complication. We sought to determine the efficacy of GUARDIX-SL which is made from sodium hyaluronate and sodium carboxymethylcellulose in soluble form. MATERIALS AND METHOD: For 7 rabbits, we made a surgical opening anterior to sinus ostium of the maxillary sinuses on both sides. We put the gelfoams soaked with GUARDIX-SL into the left openings and those soaked with normal saline into the right openings as a control group. We measured the size of the openings after two weeks. RESULTS: There was no synechiae in GUARDIX-SL group whereas we found synechiae developed in two openings in the control group. The mean area of the opening was 9.29 mm2 and 1.61 mm2 in GUARDIX-SL group and the control group (p=0.027), respectively. CONCLUSION: GUARDIX-SL was effective in reducing postoperative stenosis in the animal model.