Nerve Regeneration after Modified End-to-Side Neurorrhaphy in the Rat.
10.4055/jkoa.2005.40.7.977
- Author:
Byung Sung KIM
1
;
Moon Sang CHUNG
;
Won Sik CHOY
;
Goo Hyun BAEK
Author Information
1. Department of Orthopaedic Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea.
- Publication Type:Original Article
- Keywords:
Peripheral nerve injury;
Epineurial window area;
Contact area with donor nerve;
Nerve regeneration
- MeSH:
Animals;
Axons;
Fingers;
Hand Strength;
Humans;
Median Nerve;
Nerve Fibers;
Nerve Regeneration*;
Peripheral Nerve Injuries;
Rats*;
Tissue Donors
- From:The Journal of the Korean Orthopaedic Association
2005;40(7):977-983
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of this study was to evaluate the effect of modified end-to-side neurorrhaphy on functional recovery, by modulating the epineurial window and contact areas with a donor nerve, using a rat median nerve and finger flexors. MATERIALS AND METHODS: Four experimental groups (n=10) were used: a large epineurial window and a spiral circumferential contact with the donor nerve (Group A): a large epineurial window and half a contact with the donor nerve (Group B): a small epineurial window and half a contact with the donor nerve (Group C): and a nontransferred control (Group D). Grasping testing, muscle contractility testing, and a histological study were performed. RESULTS: Twenty weeks after surgery, the grasping strength, tetanic force and nerve fiber count were significantly higher in group A than group C. The modified end-to-side repair can enhance axonal sprouting from an intact nerve, and improve functional recovery. CONCLUSION: Either the epineurial window surface area or the contact configuration with the donor nerve is an important factor in an end-to-side coaptation model.
