The Relationship between Expression of E-Cadherin, Clinical Staging and Differentiation in Squamous Cell Carcinomas of the Head and Neck.
- Author:
Young Ah KOO
1
;
Kyoung Sup NA
;
Myoung Geun PARK
;
Kwang Sik HAN
;
Young Min PARK
;
Jung Weon SIM
Author Information
1. Department of Otolaryngology-Head & Neck Surgery, Hallym University, College of Medicine, Seoul, Korea. KNENT@chollian.net
- Publication Type:Original Article
- Keywords:
E-cadherin;
Head and neck cancer
- MeSH:
Cadherins*;
Carcinoma, Squamous Cell*;
Cell Adhesion Molecules;
Cell Differentiation;
Head and Neck Neoplasms;
Head*;
Humans;
Neck*;
Neoplasm Metastasis
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2000;43(9):967-971
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: In recent years, much attention has been directed towards cell adhesion molecules. This study was designed to confirm the significance of E-cadhcrin as a marker for differentiation and invasiveness of squamous cell carcinomas of the head and neck. MATERIALS AND METHODS: Twenty-nine patients with squamous cell carcinoma of the head and neck were used in this study. The specimens of formalin-fixed paraffin-embedded tissues were investigated by immunohistochemical analysis using monoclonal anti-E-cadherin antibody. RESULTS: The results showed that here was a statistically significant correlation in the head and neck squamous cell carcinoma between the T and the N stage and the expression of E-cadherin (p=0.025, p=0.015). The cell differentiation was also correlated with the reduction of E-cadherin (p =0.005). CONCLUSION: E-cadherin may be linked to progression and differentiation of the head and neck squamous cell carcinoma. E-cadherin immunostaining in the primary tumor appear to be a good marker for the invasiveness and the metastasis of tumors.
