Nicolau Syndrome Following Intramuscular Diclofenac Injection.
10.4055/jkoa.2015.50.4.333
- Author:
Seong Jun AHN
1
;
Suk Woong KANG
;
Bu Hwan KIM
;
Moo Ho SONG
;
Seong Ho YOO
;
Young Jun KIM
;
Dong Hwan KIM
Author Information
1. Department of Orthopaedic Surgery, Daedong Hospital, Busan, Korea. redmaniak@naver.com
- Publication Type:Case Report
- Keywords:
intramuscular injection;
nonsteroidal anti-inflammatory drugs (NSAIDs);
Nicolau syndrome
- MeSH:
Adrenal Cortex Hormones;
Anti-Bacterial Agents;
Diclofenac*;
Humans;
Injections, Intramuscular;
Korea;
Necrosis
- From:The Journal of the Korean Orthopaedic Association
2015;50(4):333-336
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Nicolau syndrome is a rare complication causing severe pain and tissue necrosis after intramuscular injection. In Korea, the Korea Dermatological Association has reported 12 cases, and some severe cases required surgical treatment. Most cases have been related to the administration of a variety of drugs, including nonsteroidal anti-inflammatory drugs, corticosteroids, and antibiotics. We present two patients who developed this complication, 1 case of typical Nicolau syndrome and 1 case of atypical Nicolau syndrome.
