A Interventional Study in a Real Life Setting to Assess the Clinical Efficacy and Effect on Fracture in the 1 Year after Injection of Zoledronic Acid in Osteoporotic Patients with Long Bone or Spine, Pelvic Fractures.
10.4055/jkoa.2016.51.4.320
- Author:
Jaewon LEE
1
;
Joonguk KIM
;
Byeungjik KANG
;
Jaedong KIM
;
Ki Chul PARK
;
Ye Soo PARK
Author Information
1. Department of Orthopedic Surgery, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea. hyparkys@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
osteoporosis;
zoledronate;
bone mineral density;
back pain;
fracture healing
- MeSH:
Back Pain;
Bone Density;
Diagnosis;
Female;
Follow-Up Studies;
Fracture Healing;
Humans;
Infusions, Intravenous;
Osteoporosis;
Osteoporosis, Postmenopausal;
Spine*;
Treatment Outcome*
- From:The Journal of the Korean Orthopaedic Association
2016;51(4):320-326
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We studied the improvement of back pain in vertebral fracture and fracture healing in non-vertebral fracture after treatment with zoledronate in postmenopausal patients. MATERIALS AND METHODS: Postmenopausal women with bone mineral density (BMD) T-score of -2.5 or less and existing vertebral fractures or non-vertebral fractures between January 2011 and June 2012 were included. Patients received a single intravenous infusion of zoledronate within 3 days after diagnosis of fractures. The primary outcome was BMD and secondary outcomes were visual analogue scale (VAS) for back pain, fracture healing, and new clinical fracture. RESULTS: T-score increased significantly in the vertebral fracture group (n=97) and non-vertebral fracture group (n=31) at 1 year (p<0.05). The average VAS for back pain decreased significantly in the vertebral fracture group (p<0.05) and there was no delayed union, nonunion in the non-vertebral fracture group. There was no re-fracture and 3 new clinical fractures (2.34%) occurred during the follow-up period. CONCLUSION: Zoledronate, as treatment in postmenopausal osteoporosis patients can improve BMD, reduce back pain in vertebral fracture, and has no negative effect on bone healing after fracture in non-vertebral fracture.
