A Study of Susceptibility between Allergic Rhinitis and IL-4 Receptor alpha Gene Polymorphism Study in Korean.
- Author:
Jae Hoon LEE
1
;
Tae Wook CHOI
;
Jung Hun LEE
;
Sang Heon LEE
;
Ha Min JEONG
;
Jung Youl MIN
;
Jeong Joong KIM
Author Information
1. Department of Otolaryngology, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, School of Medicine, Iksan, Korea. coolnose@wmc.wonkwang.ac.kr
- Publication Type:Original Article
- Keywords:
Receptor, interleukin-4;
Rhinitis, allergic;
Korean;
Polymorphism
- MeSH:
Alleles;
Binding Sites;
Cell Count;
Eosinophils;
Genotype;
Humans;
Immunoassay;
Immunoglobulin E;
Interleukin-4*;
Receptors, Cytokine;
Receptors, Interleukin-4*;
Rhinitis*
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2005;48(8):1004-1007
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: The IL-4 receptor (IL-4R) gene has been suggested as a candidate gene for atopic diseases. The IL-4R consists of two subunits: the alpha chain (IL-4Ralpha), which is a high-affinity IL-4 binding site shared with the IL-13R, and the common gamma chain shared with several other cytokine receptors that amplifies signalling of the alpha chain. A Gln551Arg polymorphism of the IL-4Ralpha gene was shown to be a gain-of-function mutation and was associated with atopy. We tested whether a Gln551Arg polymorphism of IL-4Ralpha gene is associated with allergic rhinitis, blood eosinophil counts and total serum IgE levels in the Korean population. SUBJECTS AND METHOD: Blood samples for genetic analysis were obtained from 192 individuals with allergic rhinitis and from 191 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for IL-4Ralpha Gln551Arg was used for genotyping. Serum total IgE levels were determined by using the immunoassay. Eosinophil values were determined by eosinophil numbers per total cell numbers per microL . RESULTS: There were no differences in the frequencies of the genotypes of IL-4Ralpha in the controls and patients (p>0.05). The frequencies of the IL-4Ralpha Arg551 allele were statistically different between controls and patients (p>0.05). Blood eosinophil count and total serum IgE levels were not statistically different in the genotypes of IL-4Ralpha Gln551Arg in allergic rhinitis (p>0.05). CONCLUSION: Our result suggests that the IL-4Ralpha Gln551Arg polymorphism might not give susceptibility to the development of allergic rhinitis in Koreans.
