A Study of Susceptibility between Allergic Rhinitis and IL-13 Exon 4 G2044A Gene Polymorphism Study in Korean.
- Author:
Jae Hoon LEE
1
;
Tae Wook CHOI
;
Jung Hun LEE
;
Sang Heon CHOI
;
Min Su KIM
;
Jung Youl MIN
;
Jeong Joong KIM
Author Information
1. Department of Otolaryngology, College of Medicine, Wonkwang University, School of Medicine, Iksan, Korea. coolnose@wmc.wonkwang.ac.kr
- Publication Type:Original Article
- Keywords:
IL-13;
Rhinitis allergic;
Korean;
Polymorphism
- MeSH:
Alleles;
Cell Count;
Clinical Coding;
Eosinophils;
Exons*;
Genotype;
Humans;
Immunoassay;
Immunoglobulin Class Switching;
Immunoglobulin E;
Interleukin-13*;
Polymorphism, Single Nucleotide;
Rhinitis*
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2005;48(1):61-64
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: High total serum IgE level is one of the characteristics seen in allergic rhinitis. IL-13 provides impetus to immunoglobulin class switching to IgE. The IL-13 promoter single nucleotide polymorphism has been shown to be associated with allergic diseases and abnormal IL-13 production. We tested whether a polymorphism in the coding region of IL-13 gene is associated with allergic rhinitis, blood eosinophil counts and total serum IgE levels in Korean. SUBJECTS AND METHOD: Blood samples for genetic analysis were obtained from 307 individuals with allergic rhinitis and from 268 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for IL-13 exon 4 G2044A was used for genotyping. Serum total IgE levels were determined by using the immunoassay. Eosinophil values were determined by eosinophil numbers per total cell numbers per microl. RESULTS: There were no differences in the frequencies of the genotypes of IL-13 in the controls and patients (p>0.05). The frequencies of the IL-13 exon 4 2044A allele were statistically different between controls and patients (p<0.05). Blood eosinophil count and total serum IgE levels were not statistically different in the genotypes of IL-13 exon 4 G2044A in allergic rhinitis (p>0.05). CONCLUSION: Our result suggests that the IL-13 exon 4 G2044A polymorphism might give susceptibility to the development of allergic rhinitis in Koreans.
