Morphological Changes of Cochlear Hair Cells in the Streptozotocin-Induced Diabetic Rat.
- Author:
Dae Gun JUNG
1
;
Yong Su PARK
;
Sang Hu KIM
;
Chun Il KIM
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Catholic University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Streptozotocin;
Diabetes;
Rat;
Morphology;
Cochlea hair cell
- MeSH:
Aged;
Animals;
Diabetes Mellitus;
Diabetes Mellitus, Type 1;
Hair*;
Hearing Loss;
Humans;
Injections, Intravenous;
Rats*;
Streptozocin
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
1997;40(8):1162-1170
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Diabetes Mellitus has been known as a multisystemic disorder for a long time. An association between diabetes and hearing loss was first postulated in the one case report published by Jordao in 1857. The typical hearing loss from diabetes is a progressive and bilateral sensorineural deficit that predominantly occurs in the high frequency and in the elderly patients. OBJECTIVES: The purpose of this study was to investigate the morphological changes of cochlear hair cells in the insulin-dependent diabetes mellitus induced by Streptozotocin. MATERIALS AND METHODS: Thirty two rats were used for this study and divided into control and diabetic group. Furthermore each group was subdivided into 4 weeks, 8 weeks, 12 weeks and 16 weeks group. All experimental animal were put in the same environmental condition. Insulin-dependent diabetes mellitus was induced by intravenous injection of Streptozotocin (65 mg/kg of body weight). Hair cell loss and their ultrastructural changes were observed with phase contrast light microscope and transmission electron microscope. CONCLUSION: The results of this study suggest that metabolic change of diabetes mellitus may affect the cochlear hair cells.
