Expression of p53 and Epidermal Growth Factor Receptor in the Oral and Oropharyngeal Squamous Cell Carcinomas.
- Author:
Yong Hun RHO
1
;
Seung Hak LEE
;
Wan Soo KIM
;
Kyung Il KIM
;
Bong Nam CHOI
;
Nam Yong DOH
Author Information
1. Department of Otorhinolaryngology, College of Medicine, Chosun University, Kwang Ju, Korea.
- Publication Type:Original Article
- Keywords:
p53;
EGFR;
Oral and oropharyngeal squamous cell carcinoma
- MeSH:
Carcinoma, Squamous Cell*;
Epidermal Growth Factor*;
Oropharynx;
Receptor, Epidermal Growth Factor*
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
1997;40(4):495-504
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The prognostic significance of the squamous cell carcinomas of the oral and oropharynx have been evaluated to identify those features associated with aggressive biologic behavior according to the immunologic and histologic characteristics. For determining prognostic indicators, the authors performed immunohistochemical staining of p53 and epidermal growth factor receptor(EGFR) in 29 cases of squamous cell carcinomas of the oral and oropharynx. The expression rate of p53 was 51.7%, that of EGFR was 96.6%, and overexpression rate of EGFR was 41.4%, however there were no statistical significance between the reactivity of EGFR, p53 and clinicopathological features such as primary stage, nodal stage, clinical stage, death and histologic grade.
