Differences of Zebrin II Expression Pattern Between Normal Balb/C and Ataxic Pogo Mouse Cerebellum.
- Author:
Nam Seob LEE
1
;
Chul Tae KIM
;
Ki Hyung KIM
;
Sun Kyung KIM
;
Seung Hyuk CHUNG
;
Kyong Og KO
;
Kazuhiko SAWADA
;
Yoshihiro FUKUI
;
Byung Wha HYUN
;
Moo Ho WON
;
Young Gil JEONG
Author Information
1. Department of Anatomy & Pediatrics, College of Medicine, Konyang University, Korea. ygjeong@konyang.ac.kr
- Publication Type:Original Article
- Keywords:
Zebrin II;
Cerebellum;
Ataxic pogo mouse;
Immunohistochemistry
- MeSH:
Animals;
Cerebellar Cortex;
Cerebellum*;
Dendrites;
Hand;
Immunohistochemistry;
Mice*;
Purkinje Cells
- From:Korean Journal of Anatomy
2003;36(6):457-462
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study is to identify the differences of zebrin II expression between ataxic pogo and normal Balb/C mouse cerebellum. Zebrin II is expressed by subsets of Purkinje cells that form an array of parasagittal bands that extend rostrocaudally throughout the cerebellar cortex, separated by similar bands of Purkinje cells that do not express zebrin II. Zebrin II immunoreactivity was localized in the perikarya of Purkinje cells, and the dendrites. Distribution of zebrin II-immunoreactive Purkinje cells were very similar pattern in pogo and Balb/C mouse cerebellum. But, in the lobule III, distribution of zebrin II expression was different between pogo and Balb/C mouse cerebellum. In lobule III of Balb/c mouse cerebellum, 10~15 zebrin II-immunoreactive Purkinje cells were observed and clustered to form a parasagittal bands. On the other hand, zebrin II expressions of lobule III in pogo mouse cerebellum showed a little different patterns. In lobule III of pogo mouse cerebellum, three bilateral zebrin II immunoreactive parasagittal band were observed. P1 band was almost same with lobule III of Balb/C mouse cerebellum. But, P2 bands were composed of 50~60 Purkinje cells which were immunoreactive with zebrin II. These kind of thickening in zebrin II expression of pogo mouse cerebellum may be due to the genetical difference. Furthermore, these results may provide useful information with further ataxic pogo mice cerebellum studies.
