Thyroid Hormonal Changes in Brain Death Donors.
10.4266/kjccm.2011.26.3.157
- Author:
Jae Myeong LEE
1
;
Young Joo LEE
Author Information
1. Department of Pain and Anesthesiology, Ajou University School of Medicine, Suwon, Korea. sicuab@hotmail.com
- Publication Type:Original Article
- Keywords:
brain death donor;
replacement;
thyroid hormone
- MeSH:
Brain;
Brain Death;
Female;
Humans;
Male;
Thyroid Gland;
Thyroid Hormones;
Tissue Donors
- From:The Korean Journal of Critical Care Medicine
2011;26(3):157-161
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: We analyzed thyroid hormone values in brain death patients to determine the need for thyroid hormone replacement therapy. METHODS: We analyzed 111 brain death donors (77 males and 34 females, mean age, 41.1 years (range; 8 months -72 years) in Ajou University Hospital from 2000 to 2010. RESULTS: The mean values of thyroid hormones were T3; 72.5 ng/dl (normal range [NR] 60-181 ng/dl), T4; 5.0 microg/dl (NR 4.5-10.9 microg/dl), free T4 1.0 ng/dl (NR 0.8-1.5 ng/dl), and TSH 1.5 microIU/ml (NR 0.35-5.5 microIU/ml), respectively. However, the values of T4 (correlation coefficient -0.264, p = 0.005), free T4 (correlation coefficient -0.305, p = 0.001) and TSH (correlation -0.206, p = 0.031) significantly decreased based on the increase of interval from the brain death-inducing event to the evaluation time (hereafter, interval). The patients with greater than 8 days of interval (N = 30) showed significantly low thyroid hormone values compared to patients with less than 8 days of interval (N = 81); T3 (70.3 ng/dl vs. 77.0 ng/dl, p = 0.242), T4 (4.7 ng/dl vs. 5.3 ng/dl, p = 0.015), free T4 (0.8 ng/dl vs. 1.2 ng/dl, p = 0.006) and TSH (1.0 microIU/ml vs. 2.0 microIU/ml, p = 0.000), respectively. CONCLUSIONS: As the intervals from the brain death-inducing events increased, all thyroid hormone values of brain death donors except T3 significantly decreased. Therefore, we recommend that careful consideration should be given to the interval from brain death-inducing event for the evaluation of thyroid hormone status of brain death patients.
