Re-evaluation of Association between Thrombotic Diasthesis and Legg-Calve-Perthes Disease.
- Author:
Jae In AHN
;
Won Ik LEE
;
Ye Yeon WON
;
Myeong Ryeol SONG
;
Young Ae LIM
;
Yun Sik KWAK
- Publication Type:Original Article
- Keywords:
Femoral head;
Legg-Calve-Perthes disease;
Coagulopathy
- MeSH:
Antibodies, Anticardiolipin;
Female;
Humans;
Legg-Calve-Perthes Disease*;
Lipoprotein(a);
Male;
Mass Screening;
Partial Thromboplastin Time;
Prospective Studies;
Protein C;
Protein S;
Prothrombin Time
- From:The Journal of the Korean Orthopaedic Association
1999;34(1):189-194
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Legg-Calve-Perthes disease (LCP) has been reported to be associated with hypofibrinolysis and a deficiency in coagulation. The goal of this prospective study was to confirm or refute these findings and to establish a guide for a screening test. The coagulation systems of twenty-three patients with Legg-Calve-Perthes disease were evaluated by means of the tests which included prothrombin time, activated partial thromboplastin time, antithrombin-III (AT-III), protein C, protein S, lipoprotein(a), and anticardiolipin antibody (ACA). Study subjects were 21 males and 2 females. Mean age was 8.7 years. No abnormal results were found for Antithrombin-III and Protein S, but 2 patients had low Protein C level. Two of 23 patients had Lipoprotein(a) values greater than 30 mg/dl. Another two patients had positive finding for Anticardiolipin antibody. There were no statistical differences in all parameters between Catterall group stage in the patients with Legg-Calve-Perthes disease. We were unable to establish an association between thrombotic tendency and Legg-Calve-Perthes disease based on this prospective study. So, routine screening of patients with Legg-Calve-Perthes disease for abnormalities of antithrombotic factors would be not warranted.
