Ovarian Clear Cell Carcinoma Sub-Typing by ARID1A Expression.
- Author:
Jae Yoon CHOI
1
;
Hyun Ho HAN
;
Young Tae KIM
;
Joo Hyun LEE
;
Baek Gil KIM
;
Suki KANG
;
Nam Hoon CHO
Author Information
- Publication Type:Original Article
- Keywords: Adenocarcinoma, clear cell; ovarian neoplasms; AT rich interactive domain 1A (SWI- like), human; estrogen receptor 2 (ER beta), human; endometriosis; prognosis
- MeSH: Adenocarcinoma, Clear Cell/*metabolism/mortality/pathology; Adult; Aged; Biomarkers, Tumor/metabolism; Cadherins/metabolism; Estrogen Receptor beta/metabolism; Female; Humans; Immunohistochemistry; Middle Aged; Mutation; Neoplasm Proteins/*metabolism; Nuclear Proteins/*metabolism; Ovarian Neoplasms/*metabolism/mortality/pathology; Transcription Factors/*metabolism
- From:Yonsei Medical Journal 2017;58(1):59-66
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: Loss of AT-rich DNA-interacting domain 1A (ARID1A) has been identified as a driving mutation of ovarian clear cell carcinoma (O-CCC), a triple-negative ovarian cancer that is intermediary between serous and endometrioid subtypes, in regards to molecular and clinical behaviors. However, about half of O-CCCs still express BAF250a, the protein encoded by ARID1A. Herein, we aimed to identify signatures of ARID1A-positive O-CCC in comparison with its ARID1A-negative counterpart. MATERIALS AND METHODS: Seventy cases of O-CCC were included in this study. Histologic grades and patterns of primary tumor, molecular marker immunohistochemistry profiles, and clinical outcomes were analyzed. RESULTS: Forty-eight (69%) O-CCCs did not express BAF250a, which were designated as "ARID1A-negative." The other 22 (31%) O-CCCs were designated as "ARID1A-positive." ARID1A-positive tumors were more likely to be histologically of high grades (41% vs. 10%, p=0.003), ERβ-positive (45% vs. 17%, p=0.011), and less likely to be HNF1β-positive (77% vs. 96%, p=0.016) and E-cadherin-positive (59% vs. 83%, p=0.028) than ARID1A-negative tumors. Patient age, parity, tumor stage were not significantly different in between the two groups. Cancer-specific survival was not significantly different either. CONCLUSION: We classified O-CCCs according to ARID1A expression status. ARID1A-positive O-CCCs exhibited distinct immunohistochemical features from ARID1A-negative tumors, suggesting a different underlying molecular event during carcinogenesis.
