Synthetic Bile Acid Derivative HS-1200-induced Apoptosis of Human Osteosarcoma Cells.
- Author:
Gyoo Cheon KIM
1
;
Young Soo HER
;
Jae Hyun PARK
;
Yong Suk MOON
;
Young Hyun YOO
;
Sang Hun SHIN
;
Bong Soo PARK
Author Information
1. Department of Oral Anatomy, College of Dentistry, Pusan National University, Korea. parkbs@pusan.ac.kr
- Publication Type:In Vitro ; Original Article
- Keywords:
Synthetic bile acid;
Apoptosis;
Anticancer effect;
Osteosarcoma cells
- MeSH:
Apoptosis*;
Bile Acids and Salts;
Bile*;
Caspase 3;
Cell Death;
Chenodeoxycholic Acid;
Humans*;
Osteosarcoma*;
Ursodeoxycholic Acid
- From:Korean Journal of Anatomy
2004;37(5):449-457
- CountryRepublic of Korea
- Language:English
-
Abstract:
Bile acids and synthetic its derivatives induced apoptosis in various kinds of cancer cells and had anticancer effects. However, it wasn`t discovered those materials have apoptosis induced effects on osteosarcoma cells. The present study was done to examine the synthetic bile acid derivatives induced apoptosis on osteosarcoma cells and such these apoptosis events. The synthetic bile acid derivatives, chenodeoxycholic acid (CDCA) induced the cell death on human osteosarcoma (HOS) cells contrary to ursodeoxycholic acid (UDCA). HS-1200, a synthetic derivative of CDCAs, was chosen to experiment apoptosis events in HOS cells. HOS cells treated with HS-1200 showed nucleus condensation, cytochrom c release, Bax/Bcl-xL alteration, activation of caspase-3 and caspase-activated deoxyribonuclease (CAD), and degradation of poly (ADP-ribose) polymerase (PARP). Though this study needs more investigations, these in vitro data suggest that treatment of the synthetic bile acid derivatives can give medical therapy on HOS cells.
