Expression of Preadipocyte Factor-1 (Pref-1) and Vitamin D3 Up-regulated Protein 1 (VDUP1) Genes in Rat Adrenal Gland following Chronic Immobilization Stress.
- Author:
You Kyung LEE
1
;
Jin Woon PARK
;
Su Sung SONG
;
Young YANG
;
Keon Su LEE
;
Young Ho LEE
Author Information
1. Department of Anatomy, College of Medicine, Chungnam National University, Korea. yhlee@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
Preadipocyte factor-1 (Pref-1);
Vitamin D3 up-regulated protein 1 (VDUP1);
Chronic immobilization stress;
Adrenal gland
- MeSH:
Adrenal Cortex;
Adrenal Glands*;
Adrenal Medulla;
Animals;
Cholecalciferol*;
Immobilization*;
In Situ Hybridization;
Oxidative Stress;
Pancreas;
Pituitary Gland;
Rats*;
Testis;
Vitamins*;
Zona Glomerulosa
- From:Korean Journal of Anatomy
2004;37(5):491-498
- CountryRepublic of Korea
- Language:English
-
Abstract:
Preadipocyte factor-1 (Pref-1) is expressed in the neuroendocrine organs such as the pituitary gland, the adrenal gland, the pancreas, the testis, etc. Vitamin D3 up-regulated protein 1(VDUP1) gene is known to be a novel member of early response genes as an oxidative stress mediator. The aim of the present study was to investigate whether Pref-1 and VDUP1 is involved in stress response in the adrenal gland following chronic immobilization stress. In situ hybridization for Pref-1 and VDUP1 genes (Pref-1 and VDUP1) was performed in the rat adrenal glands following immobilization stress, 2 hr once daily for 7 days. In situ hybridization analysis revealed that Pref-1 expression was up-regulated in rat adrenal medulla following chronic immobilization stress. However, Pref-1 was down-regulated in the zona glomerulosa of the adrenal cortex following chronic immobilization stress. VDUP1 expression was up-regulated in the zona glomerulosa and the adrenal medulla following chronic immobilization stress. These results show that Pref-1 and VDUP1 may be novel genes responding to chronic immobilization stress in adrenal gland.
